Src turns FHL1 to the dark side

RUNX3 loss turns on the dark side of TGF-beta signaling

O Brave New World: The Dark Side of Cyberspace

This article focuses on some of the negative aspects of cyberspace andcyberculture. First, it offers an examination of the impact of our use ofsocial media, and Facebook in particular, on our psyches, pointing out thatusers of social media can be thought of as audiences. These audiencesand information about them can be sold to marketers and advertisers.Next, it offers a case study of a widespre...

The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif.

The homing endonuclease I-Ssp6803I causes the insertion of a group I intron into a bacterial tRNA gene-the only example of an invasive mobile intron within a bacterial genome. Using a computational fold prediction, mutagenic screen and crystal structure determination, we demonstrate that this protein is a tetrameric PD-(D/E)-XK endonuclease - a fold normally used to protect a bacterial genome f...

Bringing light to the dark side.

“YOUR child’s heart stopped.” There are few more chilling words that parents can hear as they wait for a child who is in surgery. Preventing and treating this devastating event has always been of paramount concern to anesthesiologists. In this issue of ANESTHESIOLOGY, Morray et al. present important new data regarding anesthesiarelated cardiac arrest in children. These data come from the Periop...

The dark side of cosmology: dark matter and dark energy.

A simple model with only six parameters (the age of the universe, the density of atoms, the density of matter, the amplitude of the initial fluctuations, the scale dependence of this amplitude, and the epoch of first star formation) fits all of our cosmological data . Although simple, this standard model is strange. The model implies that most of the matter in our Galaxy is in the form of "dark...